1/8/2023 0 Comments Ecm biology![]() As a consequence, low back pain is one of the most common conditions for which to seek medical consultation and one of those preeminent for analgesic use in the United States. In fact, chronic low back pain may also lead to brain tissue destruction. Low back pain is a leading debilitating condition that affects every population worldwide, and can lead to diminished physical function, loss of wages, decreased quality of life, and psychological distress. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. ![]() ![]() The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The intervertebral disks along the spine provide motion and protection against mechanical loading.
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